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Microfluidic platforms for lab-on-a-chip applications

Identifieur interne : 000D40 ( Main/Exploration ); précédent : 000D39; suivant : 000D41

Microfluidic platforms for lab-on-a-chip applications

Auteurs : Stefan Haeberle [Allemagne] ; Roland Zengerle [Allemagne]

Source :

RBID : ISTEX:1EB85DFFC8C80F9D447BCC8C9CD5EB24085B1428

English descriptors

Abstract

We review microfluidic platforms that enable the miniaturization, integration and automation of biochemical assays. Nowadays nearly an unmanageable variety of alternative approaches exists that can do this in principle. Here we focus on those kinds of platforms only that allow performance of a set of microfluidic functions—defined as microfluidic unit operations—which can be easily combined within a well defined and consistent fabrication technology to implement application specific biochemical assays in an easy, flexible and ideally monolithically way. The microfluidic platforms discussed in the following are capillary test strips, also known as lateral flow assays, the “microfluidic large scale integration” approach, centrifugal microfluidics, the electrokinetic platform, pressure driven droplet based microfluidics, electrowetting based microfluidics, SAW driven microfluidics and, last but not least, “free scalable non-contact dispensing”. The microfluidic unit operations discussed within those platforms are fluid transport, metering, mixing, switching, incubation, separation, droplet formation, droplet splitting, nL and pL dispensing, and detection.

Url:
DOI: 10.1039/b706364b


Affiliations:


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Le document en format XML

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<term>Switzerland Miniaturisation</term>
<term>UCLA</term>
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<term>Anal</term>
<term>Assay</term>
<term>Assay result</term>
<term>Blood sample</term>
<term>Capillary channel</term>
<term>Capillary electrophoresis</term>
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<term>Capillary valve</term>
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<term>Carrier phase</term>
<term>Centrifugal</term>
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<term>Incubation time</term>
<term>International conference</term>
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<term>Lateral flow assay</term>
<term>Life science</term>
<term>Liquid droplet</term>
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<term>Protein crystallization assay</term>
<term>Protein solution</term>
<term>Readout</term>
<term>Reagent</term>
<term>Research community</term>
<term>Royal society</term>
<term>Sample liquid</term>
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<term>Separation channel</term>
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<term>Surface acoustic wave</term>
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<term>Tice</term>
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<div type="abstract">We review microfluidic platforms that enable the miniaturization, integration and automation of biochemical assays. Nowadays nearly an unmanageable variety of alternative approaches exists that can do this in principle. Here we focus on those kinds of platforms only that allow performance of a set of microfluidic functions—defined as microfluidic unit operations—which can be easily combined within a well defined and consistent fabrication technology to implement application specific biochemical assays in an easy, flexible and ideally monolithically way. The microfluidic platforms discussed in the following are capillary test strips, also known as lateral flow assays, the “microfluidic large scale integration” approach, centrifugal microfluidics, the electrokinetic platform, pressure driven droplet based microfluidics, electrowetting based microfluidics, SAW driven microfluidics and, last but not least, “free scalable non-contact dispensing”. The microfluidic unit operations discussed within those platforms are fluid transport, metering, mixing, switching, incubation, separation, droplet formation, droplet splitting, nL and pL dispensing, and detection.</div>
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